Mississippi's 4th congressional district covers the southeastern region of the state. It includes all of Mississippi's Gulf Coast, stretching ninety miles between the Alabama border to the east and the Louisiana border to the west, and extends north into the Pine Belt region. It includes three of Mississippi's four most heavily populated cities: Gulfport, Biloxi, and Hattiesburg. Other major cities within the district include Bay St. Louis, Laurel, and Pascagoula.
Three of Mississippi's four most heavily populated cities, Gulfport, Biloxi, Hattiesburg are in the Fourth District. Other major cities within the district include Bay St. Louis, Laurel, and Pascagoula.
Since 2013 the entire counties of Hancock, Harrison, Jackson, Pearl River, Stone, George, Marion, Lamar, Forrest, Perry, Greene, Jones, and Wayne, along with the southeastern part of Clarke are counted in this district.
Interstate 59 is an important north-south route that traverses the district, while coastal Interstate 10 serves as the major east-west route. US Highway 49 is a vital hurricane evacuation route and is four-laned from Gulfport to Jackson.
Prior to 2003, the district included most of Jackson, all of Natchez and the southwestern part of the state. Much of the black-majority area is now part of Mississippi's 2nd congressional district. In 2003, after Mississippi lost a seat in redistricting, most of the old 5th District was redefined as the new 4th District.
The perimeter of the current Fourth District extends across the ninety-mile coastal southern edge of Mississippi from the Louisiana border to the Alabama border, following the Alabama state line north along the eastern border of the state to a point due east of Quitman in Clarke County where it is bounded by the 3rd District and then moves in an irregular fashion south of Quitman until it reaches the county line with Wayne County, and then follows the northern and western borders to wholly contain Jones, Forrest, Lamar, and Marion counties until it reaches the Louisiana state line, ultimately bounded by the Pearl River winding to its outlet in Lake Borgne.